Morpholine derivative were prepared by reacting the morpholine with chloroacetyl chloride in the presence triethylamine as an catalyst and diethylether as a solvent gave the 2-(4-chloroacetyl)morpholine then reaction with substituted 2-amino benzothiazole to give new compounds (M1-M10) and reaction of 5-substituted-2-amino-1,3,4-oxadiazolein the presence of potassium carbonate anhydrous to give new compounds (M21-M30) respectively. The chemical structure synthesis compound were identified by spectral methods their (FT-IR and H1- NMR) and measurement some of its physical properties. The synthesized compounds were screened for antibacterial activity.