The Cu(II), Fe(II), Mn(II) and Zn(II) metal complexes of Schiff base 2-(salicylimino)-3-hydroxypyridine (SIHP) were prepared and characterized by various analytical techniques such as FTIR, UV-Visible spectroscopy and elemental analyses. The magnetic moment values suggested octahedral geometry for these transition metal complexes. Thermal stability of the compounds synthesized was also studied. The compounds were also screened against various microorganisms to study their antimicrobial effect. The complexes synthesized were non toxic, non electrolytic and stable solids.