Silica supported perchloric acid (HClO4:SiO2) was used as a catalyst for the synthesis of twelve tetraazamacrocyclic complexes of transition metals using chloride, nitrate and acetate salts of Co(II), NI(II), Cu(II) and Zn(II). The complexes were obtained by template condensation of ethylenediamine and glyoxal in ethanolic medium in presence of above transition metal ions using silica supported perchloric acid (HClO4-SiO2) as catalyst. The synthesized complexes have been characterized with the help of molar conductance, magnetic susceptibility measurements, IR, electronic, 1H-NMR, Mass Spectra, TGA, and powder x-ray analysis. Based on the results obtained a six coordinated octahedral geometry has been proposed for all these complexes. The synthesized complexes were also screened for their antimicrobial activity.