Thiosemicarbazones belong to a class of compounds that occupy a wide range of biological activities and have been studied for their activity against tuberculosis, virus and most important against various cancerous cells. The tetrazole moiety is a versatile lead molecule in pharmaceutical development and has a wide range of biological activities. The diverse properties of tetrazoles and Thiosemicarbazones have prompted us to synthesize them in order to study their anti-inflammatory activity which has not been reported yet. In the present work some novel thiosemicarbazones derivatives containing the tetrazole moiety are synthesized and their structures have been confirmed by FT-IR, NMR and Mass spectra and elemental analysis.