This study mainly targets a number of derivatives of thioxanthone, taking advantage of the Schiff base reaction which includes the reaction of 2-bromo thioxanthone which reaction with amines compound in the presence of glacial Acetic acid and absolute ethanol as a solvent . The preparation of compound 2-bromo thioxanthone (3), is to be used as a compound acid. The compound having heterocyclic ring is expected to have various important biological and therapeutic application. This demonstrates structural formula for each of new synthesis compound on the basis of chemical reaction , analysis of the elements, the infrared spectra and nuclear magnetic resonance .(1H NMR and 13 C NMR)