Six different hydrazine’s (hydrazine hydrate 80%, phenyl hydrazine, thiosemicarbazide, semicarbazide,2,4- dinitrophenyl hydrazine and 4- phenyl thiosemicarbazide ) were reacted with six different types of substituted chalcones α,β- unsaturated ketenes to yield pyrazole derivatives then characterized the products with infrared spectra, elemental analysis, mass spectra, 1H and 13C-NMR spectra. Finally their biological activity for some of the new pyrazoles were studied.