Synthesis, Characterization and biological study of two Schiff base ligands derived from 2-aminophenol and 4-bromoacetophenone (1:1) (L1) and boron Schiff base which was derived from L1 and sodium borohydride (1:1) (L2). Cu (II) and Pt (IV) complexes of the Schiff base ligands were synthesized. The prepared compounds have been investigated by molar conductivity, elemental analysis, FTIR, 1H 13 CNMR, thermal analysis, UV-VIS, as well as atomic absorption and magnetic susceptibility. The biological study of the ligands and their metal complexes were carried out against E-coli, Staphylococcus, as bacteria species, Candida and Mycrosporium Canis as fungi.