Thiadiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic, anti inflammatory, anti-convulsant etc.In the present study we have synthesized some substituted thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR and CHN analysis. All the values and results of this spectral and elemental analysis are found to be in the normal range. These compounds were evaluated for various biological activities like Antidiabetic, anti-inflammatory, anti-fungal activity.