Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 4

Synthesis and biological evaluation of �Ž�²-amino naphthyl substituted chalcones for anti-inflammatory and antioxidant activities

Abstract

A series of N-(naphthalene-2-yl)-3-(substituted phenyl) prop-2-enamides were synthesized by reaction of β -acetyl amino naphthalene with substituted aromatic aldehydes in presence of absolute ethanol and 30% NaOH. The intermediate β-acetyl amino naphthalene was prepared by refluxing β-amino naphthalene with acetic anhydride and glacial acetic acid. A total of nine compounds were synthesized, purified and characterized on the basis of their spectral data. The title compounds were screened for anti-inflammatory activity by carrageenan induced rat hind paw method and antioxidant activity by using nitric oxide scavenging activity and reduction of stable free DPPH. Among the series of compounds 4-methoxy (3) and 4-dimethyl amino (6) derivatives exhibited significant antiinflammatory activity. Among the test compounds 4-dimethyl amino (6) and 4-isopropyl (7) derivatives exhibited good antioxidant activity in both nitric oxide (NO) scavenging activity and reduction of stable free radical DPPH.

http://sacs17.amberton.edu/

rtp slot demo