A novel series of benzophenone amide derivatives (8a-j) were synthesized, and evaluated for their anticancer activity against human cancer cell lines like MCF-7, MDA MB-231(Breast cancer), A549 (Lung cancer). All the synthesized derivatives are first reported and adriamycin used as reference drug. Among the compounds, compounds 8b, 8h and 8j were showed more potent anticancer activity than control.