Synthesis of cinnamic acid esters 4a-c to 7 was achieved starting from appropriately substituted benzaldehydes. While compound 4a-c to 7 was exhibited potent antioxidative activity in both the NBT and DPPH-radical scavenging models among the synthesized cinnamic acid ester derivatives. No ester derivative showed significant 5-Lox, Tyrosine inhibitory and Cytotoxic activities in the present study.