The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]- Phenyl amino}-6-[Bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with guanidine hydrochloride in the presence of alcoholic potassium hydroxide. The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.