New thiazolidione thiourea of 4-methylquinoline der ivatives were synthesized from 2-nitroacetophenone by bromination followed by reduction of nitro group an d cyclization to obtain the quinoline nucleus . the structures of synthesized compounds were identified by IR, NMR a nd physical data . The newly synthesized products w ere tested for their anticonvulsant activities by PTZ induced convulsion method. All the derivatives showed moder ate to significant anticonvulsant activity at 10 mg/kg of the dose and compound 5(a) and 5(c) showed less per cent of mortality over duration of 24 h.