Chalcone have displayed an impressive array of biological importance. A new series of chalcone have been synthesized by reacting 1-(4-isobutylphenyl) ethanone with different substituted aldehyde in turn clasien-schimidt condensation. All synthesized compounds have been evaluated for anti-bacterial and anti-fungal studies. Compound 11 showed promising anti-bacterial activities against staphylococcus aureus having MIC50 value of 2.10ug/ml and compound 2 also showed good anti-fungal activity against Candida krusei having MIC50 value of 2.12ug/ml.