The pharmaceutical information service is important for pharmaceutical enterprises to promote the development of pharmaceutical enterprises, and then the application of virtual cloud technology on it is studied in depth. Firstly, the basic theories of virtualization technology and cloud computing technology are introduced. Secondly, construction meaning of information service platform of pharmaceutical enterprises are discussed. Then the system architecture for information service platform of pharmaceutical enterprises is designed. Then the architecture of cloud computing and optimal algorithm are put forward. Finally, the simulation is carried out, and effectiveness of this plat is verified.