This article designed laccase bioreactors base on characters of pharmaceutical wastewater. The experiment designed and made fluidized bed laccase bioreactor. The shape dimension was 260 mm × Φ 130 mm. The effective capacity of the laccase bioreactor was 1.5 L. The optimum conditions that fluidized bed laccase bioreactor treated pharmaceutical wastewater was reaction time 100min, mediator concentration 10mg/L, pH=5, laccase amount 35mg/L.In this condition, removal rate of chorma could reach 75% and removal rate of COD reach 67%.