Based on the analysis of literature data about modern state of solving the problem of treatment of diabetic and alcoholic neuropathy it has been grounded the necessity of application of the combined medicine on basis of pyrimidine nucleotides salts in combination with vitamins B complex, thioctic acid and magnesium lactate dihydrate in therapeutic practice. At the first stage of pharmaceutical development the technological properties of the initial active pharmaceutical ingredients and their combination (morphological properties of substances and their granulometric composition, flowability, density of bulk product and density of settled product, repose angle) have been studied. From the results of determination of technological properties of the substances it has been found that magnesium lactate dihydrate has the most optimal properties of density and flowability. It has been found that the model mixture of active pharmaceutical ingredients has unsatisfactory technological properties (flowability, density of bulk product and density of settled product, repose angle). Therefore for providing of cost-efficient manufacturing process it is necessary to optimize the investigated technological characteristics of the mixture of active pharmaceutical ingredients and enter auxiliary substances, which improve flowability of the mixture, distribution of the active pharmaceutical ingredients when capsulation, prevent balling, into its composition.