The statins are the most effective and best-tolerated agents for treating dyslipidemia. They can reduce all elevated lipids and also modestly raises High density lipoprotein -Cholesterol levels. They can reduce fatal and nonfatal coronary heart disease events, stroke, and total mortality. An open labelled cross sectioned study was conducted in the Department of General Medicine Sree Balaji medical college and hospital , Chrompet during the period of August 2015 to January 2016 .In our study ,patients on Atorvastatin had incidence of 4% abnormal elevation of liver enzymes, and patients on Rosuvastatin had incidence of 2% abnormal elevation of liver enzymes. p value was not significant (p=1).Hence this study shows that statins do not cause significant liver dysfunction and can be safely prescribed for all cases of dyslipidemia.