Original Articles: 2010 Vol: 2 Issue: 2
Studies on enteric coated sustained timed-release tablets of Metronidazole
Abstract
The present article deals with an oral dosage form proposed for the attainment of timed release drug delivery of metronidazole. Metronidazole containing matrix tablets coated with 3,4,5 & 6% w/v cellulose acetate phthalate in acetone were examined for applicability as timed release tablets with a predetermined lag time of 4-5 hrs. Different types of enteric coated tablets were prepared and there drug dissolution profile was studied in 0.1 N HCl (0 to 2hr) and PBS 6.8 (2- 24 hr) as dissolution media at 37±0.5 ºC,100 rpm by USP Apparatus-1(Basket assembly). The result indicated that the tablets with timed release functions could be prepared and,that the lag time were increased as the coat concentrations increased (3% to 6%w/v).The different kinds of timed release enteric coated tablets that showed lag time of 2 to 5.4 hrs in in- vitro dissolution in 2% w/v rat caecal content in 6.8 PBS(Phosphate buffer saline). The lag time showed a good agreement between the in- vitro test in PBS 6.8 and in -vitro test in 2% w/v rat caecal content. However the lag times were 4.5 hrs in in-vitro test in 2%w/v rat caecal content medium.