Biosorption process has been proposed as an efficient, potential, cost effective way of removing toxic metals from industrial effluents at low concentrations. In the present study a new bisorbent material Psidium guajava leaves powder was used as an biosorbent. Studies on the removal of cadmium from aqueous solutions using Psidium guajava leaves powder. The experiments were designed by Box- Behnken design method (3-1 fractional factorial design). The effect of metal concentration, pH of aqueous metal solution and weight of biomass was studied. The results indicate that the amount of Cadmium biosorbed increased with increase in metal concentration, weight of biomass and pH of the aqueous phase. Finally an empirical equation was developed to estimate the equilibrium distribution of Cadmium between Psidium guajava biomass and aqueous metal solution incorporating various parameters studied. The % biosorption decreases with an increase in temperature. The equilibrium data are well fitted by Langmuir (R=0.99), Freundlich (R=0.98), Reddlich-Peterson (R=0.94) and Tempkin (R=0.84) isotherm models in that order. The data are well represented by second order kinetics with a rate constant value of 0.089 g/(mg-min).The maximum uptake capacity is 4.28 mg/g at pH = 4, in 50 mL of the aqueous solution for 20 g/L of 38μm diameter biosorbent