To study describe the actions of antipsychotics or neuroleptics on the behavioral effects elicited by ketamine on open-field, rota rod and tail suspen sion tests in mice. A series of novel analogs of 2-[3-{4-(3-chlorophenyl)-1-piperazinyl} propyl]-1,2 ,4-triazolo [4,3-a] pyridine-3- (2H)-one hydrochloride, a potential psychoactive drug of the piperazine and triazolopyridine chemical classes that has antidepressant, anxiolytic, and hy pnotic properties were synthesized. Male swiss albino mice (25–30g) were used for the study and co mpounds were administered alone (0.1 or 0.2 mg/kg) or thirty minutes before ketamine (10 mg /Kg, ip). ketamine increased (63.3 ± 4.2) the locomotor activity compared to control, while neuro leptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, bloc ked hyperlocomotion caused by ketmine. In rota rod test, ketamine decreased (Ketamine: 15 ± 4.1) the permanence time of the animals compared to control (Control: 59 ± 0.6), but this e ffect was not observed when antipsychotics were administered alone. Pretreatment with antipsyc hotics reverted the effect of ketamine only in the rota rod. While ketamine (17.3 ± 5.6) decreased the time of immobility in the tail suspension test compared to the control (80.2 ± 10.2), the pre treatment with neuroleptics reverted this mobility. The action of antipsychotics or neurolept ics tested have exhibited encouraging results in the behavioral model induced by ketamine in mice and can be further evaluated as potential candidates for treatment of schizophrenia