A brine shrimp toxic compound has been isolated from Lantana camara L. leaves. Based on spectroscopic data (IR, 1H- NMR, 13C-NMR 1D and 2D), the structure of this compound was identified as lantanilic acid, C35H52O2. In this study, the n-hexane, ethyl acetate and methanol extracts and isolated compound showed toxic effects (LC50 34.2972; 27.4254; 133.1930 and 27.9903 μg/mL, respectively). The toxicity degree among the three extracts and isolated compound is isolated compound > ethyl acetate extract > n-hexane extract > methanol extract.