Atropine is an anesthetic drug used in anesthesia. Though the drug is being used as anesthetic but it’s potency may be increased by modifying the drug by way of molecular modification, in the present study, the drug has been modified by it’s c omplex formation with absolute methanol and conc. Sulphuric acid following standard procedure. The drug-organic compound interaction has been studied using differential pulse polarography( DPP). The results of pharmacological study indicated increased potency of modified atropine as compared to the parent drug that is atropine.