Natural products continue to play a pivotal role in modern drug discovery and development since they are superior new drug leads compared with purely synthetic compounds. The ability to procure useful quantities of natural products approved as pharmaceuticals by simple, scalable routes is emerging as an important goal in natural product synthesis. In this context, synthon disconnection approach pioneered by Prof. E. J. Corey of Harvard University is undoubtedly a useful and powerful tool in planning their synthesis for obtaining higher amounts of natural products. This paper highlights the strategic application of synthon disconnection approach in the synthesis planning of antifungal natural product ‘Pyrrolnitrin’ keeping a bird’s eye view on the works published in journals and patent literatures.