The effect of different solvent fractions of Telfairia occidentalis and Tectona grandis on immunological and haematological parameters of normal mice was investigated. Dynamogen administered at the dose of 50 mg/kg body weight served as the standard drug control. The administration of the different fractions of Telfairia occidentalis and Tectona grandis at doses of 200 and 400 mg/kg body weight for 14 days resulted in stimulation of increased production of CD4 + cells, total white blood cell (tWBC) and packed cell volume (PCV) in mice. The result showed that there was a significant (p<0.05) increase in the CD4 + counts, tWBC and percent PCV when compared to the group not given any extract which served as negative control and the group administered dynamogen. Although the different fractions of the extracts exhibited certain levels of stimulation, crude extract and ethyl acetate fraction showed the highest stimulation of immune cells investigated. These results therefore suggest that the different fractions of Telfairia occidentalis and Tectona grandis are capable of boosting immunological and haematological status in normal and may be very useful in infections and disease states.