This is a descriptive analytical study in which a comprehensive model based on spirituality was suggested after comparing several addiction prevention and treatment models. We conducted literature searches utilizing Ten search engines, namely Medline PubMed, Magiran, Google, Noormags, SID, Iranjournals, Psych INFO, ScienceDirect, Springer and ProQuest under the terms Spiritual Therapy or Spiritual Model and Addiction treatment models.