A Multicomponent Spectrophotometric method for simultaneous estimation of Ketotifen fumarate and Salbutamol sulphate in combined tablet dosage form has been proposed. Considering the absorption spectra of both analytes in the range of 220-360 nm in water, the four wavelengths of equal intervals of 40 nm were selected as 350 nm, 320 nm, 280 nm and 240 nm to produce calibration curves of mixture of analytes. The present method used inbuilt application of instrument (Shimadzu Pharm Spec 1700, UV-Visible Spectrophotometer) to quantify Ketotifen fumarate and Salbutamol sulphate in formulation. The mean % assay was found as 102.90% and 101.05% for Ketotifen fumarate and Salbutamol sulphate respectively. The method has been validated in accordance with ICH guidelines for accuracy and precision. The mean % recovery was found in range of 98.85 to 99.62% for Ketotifen fumarate and 99.08 to 100.65 % for Salbutamol sulphate, while % RSD was observed as less than 1% for precision study. The developed method was simple, accurate, rapid economical which make it suitable for routine analysis of Ketotifen fumarate and Salbutamol sulphate from marketed formulation.