The study aims to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation of cefixime and ofloxacin in tablet dosage forms. Pure drug samples of cefixime and ofloxacin were dissolved in a mixture of methanol and 0.1N HCl (1:1). Two wavelengths selected for formation and solving the simultaneous equations were 285.8nm for cefixime and 296.6nm for ofloxacin. Absorptivity coefficients for cefixime at 285.8nm and 296.6nm were 61.14cm-1gm-1l and 65.68cm-1gm-1l, respectively, while the respective values for ofloxacin were 75.33cm-1gm-1l and 103.62cm-1gm-1l. The recovery studies were found close to 100 % that indicates accuracy and precision of the proposed methods. The statistical analysis was carried out and results of which were found satisfactory. Standard deviation values were found low that indicated reproducibility of the proposed methods. Based on results the developed methods could be used for routine estimation of cefixime and ofloxacin from combined dosage formulations.