A highly sensitive, simple and selective HPTLC method has been established for the assay determination as well Inprocess quality control of the Tolterodine and Tamsulosin in bulk as well as in capsule formulation. Separation of Tolterodine tartrate and Tamsulosin HCl was carried out on silica gel 60F254 backed on aluminum foil, 20 × 10 cm thin layer chromatography (TLC) plates with 6 mm band and 3 μl injection volume. Ascending chromatography TLC plate developed using mobile phase containing methanol: ethyl acetate: triethylamine in the ratio (5:5:0.3 v/v/v) with 30 min prior chamber saturation. The regression analysis was carried out of seven point calibration curve using 480-1920 ng/band and 48-192 ng/band concentration for Tolterodine tartrate and Tamsulosin HCl, respectively. The correlation coefficient found 0.999 for both the drugs. The limit of detection values of the compounds were 13.26 ng/band and 22.44 ng/band as well as limit of quantification values were found 44.34 ng/band and 74.85 ng/band for Tamsulosin HCl and Tolterodine tartrate. Densitometric signal was monitored at wavelength of 220 nm. Method was validated for solution stability, specificity, accuracy, precision, limit of detection and quantification, linearity, and robustness were statistical evaluation of the method proves that, method is highly robust accurate and precise for the intended use.