A simple, rapid and precise reversed-phase liquid chromatographic method is developed for simultaneous determination of Flunarizine dihydrochloride, Domperidone and Paracetamol in combined pharmaceutical dosage form. This method uses an Eclipse XDBC-8 column, length- 4.6 x 150mm, 5μm column. Mobile phase is Acetonitrile and Water (90:10, v/v). The instrumental settings are at a flow rate of 0.8mL/min; the column temperature is 25°C and detector wavelength is 210nm. The sample concentrations are measured on weight basis to avoid the internal standard. The method is validated and shown to be linear. The correlation coefficients for Flunarizine dihydrochloride, Domperidone and Paracetamol are 0.996, 0.999 and 0.995, respectively. The recovery values for Flunarizine dihydrochloride, Domperidone and Paracetamol ranged from 99.48–101.33%, 100.96–102.05% and 99.08–102.58%, respectively. The relative standard deviation for six replicates is always less than 2%. This HPLC method is successfully applied to the simultaneous quantitative analysis of the title drugs in tablets.