A Continuous Stirred Tank Reactor (CSTR) is a highly non linear process particularly when chemical reaction takes place. The heat energy will be either liberate or absorbed by the reactor due to the reaction. The control of temperature for this process is a real challenge due to non linear temperature changes during reaction. This paper compares the performances of the Proportional Integral Derivative Controller (PID) controller, Fuzzy PID Controller, Model Predictive Controller (MPC) and MPC based PID Controller. The mathematical model of CSTR is obtained and the state space model is derived. The various controllers have been designed and performances were compared for the CSTR process. The proposed MPC-Based PID controller shows better control of temperature than the other controllers like PID and MPC.