Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 10

Serum survivin levels and their relationship to histological parameters in breast cancer patients

Abstract

This study was conducted to investigate the serum l evels of survivin and the relationship with known h istological parameters in breast cancer patients. Fifty-four pa tients with newly diagnosed breast cancer and 25 h ealthy volunteers were enrolled. Serum samples were collec ted from the patients before Chemotherapy. Serum su rvivin concentrations were measured using enzyme-linked im munosorbent assay (ELISA). Serum survivin levels in patients were not significantly different from controls (p=0 .204). Also, survivin concentrations were not signi ficantly related to age and histological parameters in patients with breast cancer except for nodal involvement. Serum survivin levels were significantly higher in patients with n odal involvement compared with node negatives (p=0. 03). However, serum survivin levels were not influenced by the number of involved nodes (p=0.78). In conclu sion, our study suggests that serum survivin levels could be a sensitive marker for detecting metastases in lymp h nodes in breast cancer patients by ELIZA technique.

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