Focusing on the problems of large-scale medical equipment allocation in medical institutions, such as improper allocation , high rate of capital employed, unfairness and so on, based on the data collected related to the operating frequency of five-type large-scale medical equipments, apply the linear programming of operational research into the analysis of the operating frequency of equipments. On the basis of daily available time of equipment, monthly average testing number of patients, non-negativity of decision variable as well as other factors, list the corresponding constraint conditions, and then establish the linear programming model of profit maximization for hospital. Employ EXCEL to obtain the solution of the model, raising the proposal concerning the standard of large-scale medical equipment allocation referring to the result of sensitivity analysis. Aim: provide a scientific and reasonable management method to the hospital administrators, improving the feasibility and practicability of the management plan.