Two simple, accurate and sensitive methods for determination of flurbiprofen (FLUR) in pure and dosage forms had been developed and validated. The first method is based on the formation of ion-associate complexes between the drug and arsenazo I (ARS I) or Bromophenol blue (BPB) to give colored products maximally absorbed at 556 and 635 nm with the two reagents, respectively. The optimum conditions that favor the formation of the ion pair complexes were extensively studied and optimized. Beer's law was obeyed up to 90.20 and 100.85 μgmL-1 while Ringboom concentration ranges are 1.89 - 89.20 and 2.00 – 96.60 μgmL-1 for the two reagents, respectively. In the second method, first derivative (1DD) spectrophotometry was used for the determination where it was found that FLUR exhibits maximum amplitude at 259 nm. At this wavelength, linear relation between concentration and absorbance was obtained with high correlation coefficients. The methods were validated, in terms of accuracy and precision and the results are satisfactory. The proposed methods were successfully applied for determination of FLUR in pure and pharmaceutical dosage form without interference from the common excipients. The results obtained by the proposed methods were comparable with those obtained by reference methods.