Medicinal plants are used in traditional treatments to cure variety of diseases. In the last few decads there has been an exponential growth in the field of herbal medicine. Infectious diseases caused by bacteria, fungi, viruses and parasites remain a major threat to public health. Despite tremendous progress in human medicine. Their impact is particularly great in developing countries because of the relative unavailability of medicines and the emergence of widespread drug resistance. The leaves Melia composite are useful in cough, wounds, ulcer, cold, sores, skin diseases, itches etc. Base on the above information the present work is aimed screen the phytochemicals and to analysed the antimicrobial activity against Enterobacter aerogenes and Shigilla flexneri. In the study, as saponin, tannins, flavanoids, carbohydrates, amino acids and protein were present in both aqueous and methanol extracts. Shigilla flexneri showed significant zone of inhibition in methanolic extract when compared to aqueous extract, Enterobacter aerogenes showed no significant difference between aqueous and methanolic extract. From the result it is concluded that both methanol and aqueous extracts shows the presence of majority of phytoconstituents and anti microbial activity. Hence this plant was may selected for the pharmacological studies. Further studies are needed to identity the pure component and establish the extract mechanism of action for antibacterial action of the plant extract.