Noninvasive treatment of Neurological diseases is limited because of poor transport of drug molecules into brain. Almost all drugs and therapeutic agents do not reach to brain due to presence of defensive barrier of brain such as Blood Brain Barrier and Blood – Cerebrospinal Fluid Barrier. Therefore main challenge for CNS drug delivery is how to maintain therapeutic concentration of drug molecules in brain. Nanotechnology gives promising solutions to overcome these obstacles. Different nanocarriers such as Liposomes, Solid lipid nanoparticles, Micelles have been studies for the drug delivery across the brain. Many nanoformulations can transport drug molecules into brain in in vitro and in vivo models. Many studies have been done to access the nanotechnology against CNS disorders such as brain tumour, Alzheimer’s disease and acute ischemic stroke. In future nanaocarriers will be promising alternative to increase brain drug concentration using novel drug delivery systems which will improve Blood brain barrier permeability and reduce their neurotoxicity.