The authors evaluated the role of flavonoids morin, rutin, quercetin and anti-oxidant vitamin-E on doxorubicin-induced oxidative stress. For this study, thirty New Zealand white rabbits aged between 5-6 months and averaging 2.5-3.0 kg in weight were used and divided into 5 groups of 6 in each. They were pre-treated with vitamin E (50 IU/kg body weight) and flavonoids morin, rutin and quercetin (20mg/kg body weight) for four weeks and two doses of doxorubicin (10mg/kg body weight) at the end. The flavonoids shown a potential protective effects on the levels of serum enzymes SGOT, SGPT, ALP, minerals sodium, potassium and phosphorus, oxidative markers catalase (CAT), lipid peroxidation, glutathione-s-transferase (GST), reduced glutathione (GSH) in whole erythrocytes and in the tissues of liver, heart and kidneys. The current study concludes that the flavonoids have an ameliorative role in the reduction of doxorubicin-induced oxidative stress. So, it was suggested that flavonoids were an effective natural anti-oxidants.