Iron is one of an element of periodic table with 26 atomic numbers. This element exists in second abandon of transition metal and it exists in earth’s crust in fourth abundant. It found in the middle and in the first transition row of predict table. Mostly this metal presented in two forms of oxidation state II (d6) and III (d5). Overloading of iron and the infections of hemochromatosis are mostly common in humans and it is treatable circumstances. This excessiveness of iron overload has a genotypes said that HFE, most study recommended that it need a multiethnic primary care for affected population. The synthesis and characterizations of transition metal have important things. Most of transition metals have medicinal proprieties. Due to this metal have improvements in transfusion therapy in beta-thalassemia major patients; Trans fissional become the major cause of late morbidity and mortality. In the entire world spatially in developing country chelating therapy is best but it is expensive. For example in India and other developing countries, iron chelation therapy is still not strictly adhered to in these children, mostly due to financial constraints. An orally effective and cheap iron chelator is the need of the hour in the treatment of beta-thalassemia major. With the advent of Deferoxamine, Deferiprone and Deferasirox, there is new enthusiasm in this front. The main aim of this review gives the ways of chemotherapy, mechanism and the globally existence of those removed iron overload in our body.