The present review outlines the synthesis and different biological activities of 1,3,4 thiadiazole and its derivatives. 1,3,4 thiadiazole has been studied extensively because of its wide variety of biological activities such as antimicrobial, anti-inflammatory, analgesic, anti-cancer, anti-tubercular and diuretic etc. However, The wide range of therapeutic values of 1,3,4 thiadiazole has encouraged us to do advance research on it.