Obesity can be considered as a chronic, systemic low-grade inflammation state induced by different inflammatory cytokines. The chronic inflammation in obesity may be a result of hypoxia in adipose tissue, macrophage infiltration to vascular wall and endocytoplasmic reticulum stress. Studies have shown that long-time regular exercise training can lower the levels of inflammatory markers and reduce the inflammation in obesity. Exercise training may reduce chronic inflammation by promoting the release of muscle-derived IL-6, increasing the total adipose tissue oxygenation, inhibiting the macrophage infiltration, reducing the number of pro-inflammatory monocots, down regulating the Toll-like receptor expression, increased the number of regulatory T cells. It will provide new ideas for the clinical treatment of chronic inflammation through further investigating the molecular mechanisms by which exercise training reduces chronic, systemic inflammation in obese individuals.