The introduction of the error proofing theory and methods is conductive to preventing enterprises from errors in quality management, reducing potential risks in the process of quality management and improving the stability of quality management. From the perspective of the two sides of quality management, the paper discusses how to apply the theory and methods of error proofing in the enterprises quality management. Based on this, the paper explains the definition and key elements of quality management error proofing. From a holistic perspective and systematic view, the paper constructs a conceptual frame of enterprises quality management error-proofing system and discusses the operational mechanism of the enterprises quality management error-proofing system with the analysis of the process of quality management error proofing.