Based on the analysis of the mechanism and hazards of asphalt fume, by adding two fume suppressant Mg(OH)2 and Al(OH)3 and two viscosity reducers Sasobit and ROADBIT-BPL, the paper optimized the mixture ratio for road use, and prepared the environment-friendly fume-suppression asphalt, and then conducted the performance tests to identify the optimum dosage. The results show that: the fume amount caused by the 10.0% dosage of Al(OH)3 will be reduced by 7.6% than the matrix asphalt; the admixture of the above two agents has negative effects on the asphalt anti-crack performance in low temperature. The anti deformation ability and high temperature stability of fume-suppression asphalt are relatively good in the optimized scheme 3.0%Sasobit+10.0% Al(OH)3.