This paper discusses the existing problems in the management of university laboratory, introduced the Internet of Things technology and its development, and the system structure are introduced. On this basis, introduces the design of Laboratory of intelligent Internet of Things technology and comprehensive management system and implementation ideas based on. The system includes equipment management, laboratory management, security management and other related modules, each module has a corresponding sub module. To achieve a real-time and efficient supervision of the laboratory for a full range of. The operation of the system to improve the efficiency of the use of laboratory resources, reduce the energy consumption of the laboratory, greatly improve the management level and laboratory safety laboratory.