The research on computer-assisted language learning in college English has been fruitful in China. But aiming at general English teaching in colleges, the research in this field has been neither detailed nor in-depth enough. Although researches on CALL reading have been springing up these years, very few related researches are seen in China. Reading is essential to acquiring overall proficiency in English for learners. However, quite a few college students are basically weak in English and lack the motivation to further study. The current monotonous teaching media and boring teaching methods of English reading make things worse. Therefore, it becomes especially urgent to improve and enrich the teaching media and teaching methods of English reading in colleges so as to further improve the teaching efficiency and effectiveness, and better stimulate students’ interest and initiative in learning English. In this paper, an experiment was conducted to discuss and explore the necessity, possibility and feasibility of applying CALL in college English reading.