The recent findings related to cell cycle re-entry mediated neurodegeneration in post mitotic neurons have triggered rampant research in this area. Cell cycle has been identified as a true, causative phenomenon occurring during prodromal stages of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Heat shock proteins are internal ‘stress absorbing’ machinery which comes into force to protect the cell against heat, oxidative stress. Owing to its chaperonic activity, HSP70 has been shown to mediate pro-survival pathways in several diseases including neurodegenerative diseases. We therefore set out to check whether HSP70 inducing compounds can be repurposed to target post-mitotic cell division. Various in silico methods such as homology modelling, Ramachandran plots, Lipinski filter, ADMET analysis and molecular docking studies were performed. We report novel potential of some HSP70 inducing compounds in ameliorating post-mitotic cell division led neurodegeneration which has wide implications in Alzheimer’s disease and Parkinson’s disease.