Medication error is any avoidable practice that may direct to harm the patients or increase cost on patient directly or indirectly. While prescribing, dispensing or administering medication to patient any mistake may lead to harm the patients. The practice of medication error is most common in developing countries including Pakistan. The present study was carried out to analyze different type of medication errors during prescribing, dispensing or during administration of drugs and to find out the measure for the control of these error in order to save the life of general population or to decrease hospitalization or to decrease cost on patients. The aim of study was also to find the prevalence of medication errors & promote safety in use of medication by ensuring effective utilization of pharmacist in ward setting. The present study was conducted in the nephrology ward of 500- bed multidisciplinary tertiary hospital located at Peshawar Kpk. It was prospective study in which 60 patients histories were analyze for medication related error and then reported by pharmacist in nephrology ward. Data from each patient were collected through special profarma which include demographic of patients, medication record, dosage form of medication, previous medication record, previous surgical history, adverse reaction, medication error, any drug interaction. Then after collecting data of each patient were evaluated for rational therapy and any medications related error analyze were then reported in order to prevent the reoccurrence of such error. In this study population of n= 60 (female 39 & male 21). Female were more prone to chronic kidney failure. CKD ratio was found greater in age of 40-60 year. Diabetic mellitus and hypertension were the two main risk factors associated with CKD the ratio of which was 20% and 53.33% respectively. Total of 87 drug related error were observed among them 45% were drug-drug interactions. 22% of interactions were of clinically significant need close attentions.Chronic kidney disease is now a day a prominent disease associated with hypertension and diabetic mellitus. Need proper assessment in order to prolong life and decrease hospitalization by providing rational therapy by avoiding all medication errors. Medication errors are avoidable events and it is the prime responsibility of pharmacist to detect it and handle it by discussing with health care professional like physician and nurses.