Polyurethane foam functionalized with isothiouronium group (ITPUF) was prepared and characterized using infrared and ultraviolet/visible spectra, bulk conductivity, iodine number, methylene blue value, zero point charge, and elemental analysis. The new sorbent has a highly capacity and good stable in acidic and alkaline solutions. The efficiency of ITPUF for removing of hazardous compounds e.g. brilliant green (BG) and direct blue (DB) dyes from wastewater were investigated with the batch and dynamic techniques. The percentages of dyes removed (80-100%) from wastewater were at pH range 2-10 and 1-7 within 3-5 min. Freundlich, Langmuir, Temkin, Harkins Jura, and Dubinin-Radushkevich adsorption models were applied to describe the removing mechanism and the equilibrium isotherms data were estimated. The capacity of ITPUF for BG and DB were 0.38 and 0.19 mmol/g. The kinetic nature of removing process was analyzed using different mathematical models and that provided the values of second order rate constant (k2) are 4.43 and 0.45 μmol g/min, respectively. The results obtained indicate that confirming the suitability of ITPUF as a new sorbent for removing of dyes from wastewater.