Molecular interaction such as solute-solute, solute-solvent and solvent-solvent interactions in the substituted azomethine drug in the different percentage of organic solvent has been pointed out. In the present work refractive index and the densities of the substituted azomethine in different percent of various organic solvents were reported. The data thus helps to determines Molar refraction (Rm) and polarizability constant (α) of some different substituted azomethine in binary mixture. Observations showed that the molar refraction and polarizability constant of substituted azomethine drugs increases with increase in percent composition of organic solvents.