Cationic solid lipid nano particles is a new trend in nano medicine family .Due to its cationic nature genes, proteins, enzymes, hormonal delivery is possible al ong with selective drug in targeted cells. This rev iew discuss about mechanism involving cationic nano drugs to re ach in target cells, it also speaks about various c ationic surfactant used in forming cationic solid lipid nan o particles. In modern time so many excavation and achievements took place on cationic solid lipid nano particles, we discussed recent formulation approaches in short .This review helps to understand significantly the challenges of cationic solid lipid nano particles in recent time .