Quinoline-4-carboxylic acid is a very important structure in a synthetic medicinal chemistry. Compounds including a quinoline-4-carboxylic acid have a wide biological range as a pharmacophore in medicinal chemistry. Many methods have been developed for the synthesis of important quinoline moiety. However, some efficient methods have been found but methods are always correlate with the toxic, corrosive catalysts, poor yieldsand longer reaction time not environmentally friendly. In this review we have describe a methods which, some scientists are working under method developed in recent advances. Quinoline-4-carboxylic acid were evaluated in biological activities like antimicrobial, antifungal and tested against inhibitors.